Clozapine in Borderline Personality Disorder and Intellectual Disability: A Case Report of Four-Year Outcome
Asit B. Biswas, MRCPsych, Simon Gibbon, MBBS & Satheesh K. Gangadharan, MRCPsych

Evidence on the usefulness of clozapine in people with borderline personality disorder is becoming more readily available. While most of the research points to the significant initial improvement, there is a paucity of information on the long-term outcome. Evidence on the use of clozapine in people with the dual diagnoses of intellectual disability and borderline personality disorder is also lacking. This case report highlights the sustained global improvement in a person with mild intellectual disability and borderline personality disorder with a low dose of clozapine. Follow up over a four-year period indicates the potential for developing long-term side effects, the need for monitoring and regular risk-benefit analysis with the active involvement of the individual receiving treatment in decision making.